Appointment: Associate Professor, School of Biological Sciences
Assistant Chair (Lifelong Learning), School of Biological Sciences (SBS)

Research topics:
• focus on the study of the mechanisms of pre-messenger RNA splicing in human cells
• identify new therapeutic targets, and/or to develop RNA-based therapies for human diseases

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1 to 6 of 6 Results
PD-L1 alternative splicing
Dec 6, 2023 - PD-L1 alternative splicing XR
Roca Castella, Francesc Xavier, 2023, "PD-L1 alternative splicing", https://doi.org/10.21979/N9/MICQRU, DR-NTU (Data), V1
PhD thesis of Dr Yashu Zhen, graduated in 2022. All data in thesis pertains to this project. Publication being put together with these data and new experiments being finished.
Thesis_Amendment Final Version_Zhen Yashu.pdf
Dec 6, 2023 - PD-L1 alternative splicing
Adobe PDF - 7.6 MB - MD5: 4f4df7d8e2f8dc5dc6c2107063b974f0
Thesis with all data so far for this project
Excel file with DASEs for Lorenzini et al (Roca) RNA 2019
May 27, 2019 - Supporting data for Lorenzini et al RNA 2019
Roca Castella, Francesc Xavier, 2019, "Excel file with DASEs for Lorenzini et al (Roca) RNA 2019", https://doi.org/10.21979/N9/3RYIVP, DR-NTU (Data), V1, UNF:6:fIX5Bo5JAZnoC+WXEh4DBQ== [fileUNF]
7 RNA-seq samples for K562 cells, PRPF40B knockout and rescue with WT or MDS mutant PRPF40B. Excel file with Differential Alternative Splicing Events (DASEs) from RNA-seq data using rMATS.. Only events that pass the cutoffs.
DASE(PRPF40B)_sorted.tab
May 27, 2019 - Excel file with DASEs for Lorenzini et al (Roca) RNA 2019
Tabular Data - 87.5 KB - 22 Variables, 380 Observations - UNF:6:fIX5Bo5JAZnoC+WXEh4DBQ==
Excel file with DEGs for Lorenzini et al (Roca) RNA 2019
May 27, 2019 - Supporting data for Lorenzini et al RNA 2019
Roca Castella, Francesc Xavier, 2019, "Excel file with DEGs for Lorenzini et al (Roca) RNA 2019", https://doi.org/10.21979/N9/MUULD6, DR-NTU (Data), V1, UNF:6:s7n2Wk81UQPaJyi6yrLKdg== [fileUNF]
DEGs and other gene expression data from RNA-seq data. 7 RNA-seq samples for K562 cells, PRPF40B knockout and rescue with WT or MDS mutant PRPF40B. Excel file with all the Differentially Expressed Genes (DEGs). Significant DEGs labeled 'Yes', others 'No'.
DEGs(PRPF40B)_sorted.tab
May 27, 2019 - Excel file with DEGs for Lorenzini et al (Roca) RNA 2019
Tabular Data - 5.0 MB - 14 Variables, 37617 Observations - UNF:6:s7n2Wk81UQPaJyi6yrLKdg==
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