Appointment: Associate Professor

Research topics:

• Lipid Regulations in Eukaryotes

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1 to 8 of 8 Results
Oct 31, 2022
Thibault, Guillaume; Yap, Wei Sheng, 2022, "A new combinatorial megaplasmid library assembly method designed to screen for minimal pathways by using SCRaMbLE",, DR-NTU (Data), V1, UNF:6:5KJyBwAUciUBv92jsbfKDg== [fileUNF]
Human proteins expressed in yeast are common to enhance protein production while the expression of functional human pathways remain challenging. Here, we propose a simple and economical high-throughput gene assembly method to create a yeast megaplasmid library from human cDNA to...
Sep 27, 2022
Thibault, Guillaume; Beaudoin-Chabot, Caroline; Wang, Lei; Celik, Cenk; Khalid, Aishah Abdul; Thalappilly, Subhash; Koh, Jhee Hong; Xu, Shiyi; Lim, Venus Wen Xuan; Low, Ann Don, 2022, "Replication Data for: The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans",, DR-NTU (Data), V1, UNF:6:bDcV8UXFkGMeff3EFRkBYA== [fileUNF]
Metabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show that Caenorhabditis elegans...
Sep 26, 2022
Thibault, Guillaume; Yap, Wei Sheng, 2022, "Human PERK rescues unfolded protein response-deficient yeast cells",, DR-NTU (Data), V1
Protein folding and quality control is tightly regulated at the endoplasmic reticulum (ER), and its disruption is associated with many diseases. In eukaryotes, the accumulation of unfolded protein in the ER is sensed by the three sensors, IRE1, PERK, and ATF6 to activate the unfo...
Apr 20, 2021
Thibault, Guillaume, 2021, "Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins",, DR-NTU (Data), V1
Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. Phospholipid perturbation has been associated to cellular stress responses. However, in most cases, the implication of membrane lipid changes to ho...
Nov 13, 2020
Thibault, Guillaume; Yap, Wei Sheng; Shuy, Peter Jr.; Marvalim, Charlie, 2020, "Replication Data for: The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis",, DR-NTU (Data), V2
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage inducing transmembrane (FIT) family induces LD formation. Here, we establish a model system to study the role of S. cerevisiae FIT homologues (ScFIT), SCS3 and YFT2, in proteosta...
Jun 18, 2020
Ho, Nurulain; Yap, Wei Sheng; Xu, Jiaming; Wu, Haoxi; Koh, Jhee Hong; George, Bhawana; Chong, Shu Chen; Taubert, Stefan; Thibault, Guillaume, 2020, "Replication Data for: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress",, DR-NTU (Data), V1
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised,...
May 27, 2020
Beaudoin-Chabot, Caroline; Lei, Wang; Shchepinov, Mikhail S.; Smarun, Alexey V.; Vidović, Drasko; Thibault, Guillaume, 2020, "Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans",, DR-NTU (Data), V1, UNF:6:vX21yKAg/6svjOec2AP1IA== [fileUNF]
Chemically reinforced essential fatty acids promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essen...
May 27, 2020
Koh, Jhee Hong; Lei, Wang; Beaudoin-Chabot, Caroline; Thibault, Guillaume, 2020, "Replication Data for: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress",, DR-NTU (Data), V1
Metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), are emerging as epidemics that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Perturbation of endoplasmic reticulum (ER) homeostasis...
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