RUEDL Christiane

Appointment: Associate Chair (Research), School of Biological Sciences
Professor, School of Biological Sciences

Research topics:

• Immunology
• Macrophages
• Cancer Immunology

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1 to 6 of 6 Results

Turnover kinetics of pancreatic macrophages in lean and obese diabetic mice Jan 20, 2024 Ruedl, Christiane; Ma, Ziyuan, 2022, "Turnover kinetics of pancreatic macrophages in lean and obese diabetic mice", https://doi.org/10.21979/N9/2YJP6X, DR-NTU (Data), V2 Pancreatic resident macrophages, a heterogeneous family of cells with distinct origins and phenotypes, are the main myeloid cells in exocrine and endocrine tissues. Adult exocrine F4/80hi macrophages consist of three different subsets based on the embryonic marker Tim-4 and MHC I...
Intranasal Delivery of RIG-I Agonist Drives Pulmonary Myeloid Cell Activation in Mice Jun 11, 2022 Nair, Sajith; Wu, Yilun; Nguyen, Trinh Mai; Fink, Katja; Luo, Dahai; Ruedl, Christiane, 2022, "Intranasal Delivery of RIG-I Agonist Drives Pulmonary Myeloid Cell Activation in Mice", https://doi.org/10.21979/N9/XYX2FS, DR-NTU (Data), V1 Viral respiratory infections cause substantial health and economic burden. There is a pressing demand for efficacious vaccination strategies and, therefore, a need for a better understanding of the mechanisms of action of novel potential adjuvants. Here we investigated the effect...
Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions Oct 19, 2021 Chen, Qi; Nair, Sajith Kumar; Ruedl, Christiane, 2021, "Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions", https://doi.org/10.21979/N9/XBXJPP, DR-NTU (Data), V1 The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbi...
Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease Oct 6, 2021 Wu, Xiaoting; Saito, Takashi; Saido, Takaomi C.; Barron, Anna M; Ruedl, Christiane, 2021, "Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease", https://doi.org/10.21979/N9/9RCHLK, DR-NTU (Data), V1 Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady-state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in neurodegenerative disorders r...
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice Mar 22, 2021 Chen Qi; Lai Simin; Xu Shaohai; Tan Yingrou; Leong Keith; Liu Dehua; Tan Jiachi; Naik Roshan Ratnakar; Barron Anna M; Sunil S. Adav; Chen Jinmiao; Chong Shuzhen; Ng Laiguan; Ruedl Christiane, 2021, "Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice", https://doi.org/10.21979/N9/9J9BWD, DR-NTU (Data), V1 Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity-driven WAT remodeling remains controver...
Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. Dec 20, 2017 Soncin, Irene; Sheng, Jianpeng; Chen, Qi; Foo, Shihui; Duan, Kaibo; Lum, Josephine; Poidinger, Michael; Zolezzi, Francesca; Karjalainen, Klaus; Ruedl, Christiane, 2017, "Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.", https://doi.org/10.21979/N9/EQXCRF, DR-NTU (Data), V1 Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that, a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neon...

Turnover kinetics of pancreatic macrophages in lean and obese diabetic mice

Jan 20, 2024

Ruedl, Christiane; Ma, Ziyuan, 2022, "Turnover kinetics of pancreatic macrophages in lean and obese diabetic mice", https://doi.org/10.21979/N9/2YJP6X, DR-NTU (Data), V2

Pancreatic resident macrophages, a heterogeneous family of cells with distinct origins and phenotypes, are the main myeloid cells in exocrine and endocrine tissues. Adult exocrine F4/80hi macrophages consist of three different subsets based on the embryonic marker Tim-4 and MHC I...

Intranasal Delivery of RIG-I Agonist Drives Pulmonary Myeloid Cell Activation in Mice

Jun 11, 2022

Nair, Sajith; Wu, Yilun; Nguyen, Trinh Mai; Fink, Katja; Luo, Dahai; Ruedl, Christiane, 2022, "Intranasal Delivery of RIG-I Agonist Drives Pulmonary Myeloid Cell Activation in Mice", https://doi.org/10.21979/N9/XYX2FS, DR-NTU (Data), V1

Viral respiratory infections cause substantial health and economic burden. There is a pressing demand for efficacious vaccination strategies and, therefore, a need for a better understanding of the mechanisms of action of novel potential adjuvants. Here we investigated the effect...

Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions

Oct 19, 2021

Chen, Qi; Nair, Sajith Kumar; Ruedl, Christiane, 2021, "Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions", https://doi.org/10.21979/N9/XBXJPP, DR-NTU (Data), V1

The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbi...

Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

Oct 6, 2021

Wu, Xiaoting; Saito, Takashi; Saido, Takaomi C.; Barron, Anna M; Ruedl, Christiane, 2021, "Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease", https://doi.org/10.21979/N9/9RCHLK, DR-NTU (Data), V1

Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady-state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in neurodegenerative disorders r...

Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice

Mar 22, 2021

Chen Qi; Lai Simin; Xu Shaohai; Tan Yingrou; Leong Keith; Liu Dehua; Tan Jiachi; Naik Roshan Ratnakar; Barron Anna M; Sunil S. Adav; Chen Jinmiao; Chong Shuzhen; Ng Laiguan; Ruedl Christiane, 2021, "Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice", https://doi.org/10.21979/N9/9J9BWD, DR-NTU (Data), V1

Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity-driven WAT remodeling remains controver...

Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.

Dec 20, 2017

Soncin, Irene; Sheng, Jianpeng; Chen, Qi; Foo, Shihui; Duan, Kaibo; Lum, Josephine; Poidinger, Michael; Zolezzi, Francesca; Karjalainen, Klaus; Ruedl, Christiane, 2017, "Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.", https://doi.org/10.21979/N9/EQXCRF, DR-NTU (Data), V1

Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that, a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neon...

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