Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.

Version 1.2
Soncin, Irene; Sheng, Jianpeng; Chen, Qi; Foo, Shihui; Duan, Kaibo; Lum, Josephine; Poidinger, Michael; Zolezzi, Francesca; Karjalainen, Klaus; Ruedl, Christiane, 2017, "Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.", https://doi.org/10.21979/N9/EQXCRF, DR-NTU (Data), V1
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Description
Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that, a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80hi cells. In colon adenomas of ApcMin/+ mice, F4/80hiMHCIIlow macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, pro-tumoural F4/80hiMHCIIlow and F4/80hiMHCIIhi subpopulations can self-renew in the tumour and maintain their numbers mostly independently of a bone marrow contribution. In summary, the tumour microenvironment creates an isolated niche for tissue-resident macrophages that favours macrophage survival and self-renewal.
Subject Medicine, Health and Life Sciences
Keyword Tissue-resident macrophages, Self-renewal, Lamina Propria, Colorectal cancer
Related Publication Soncin, I., Sheng, J., Chen, Q., Foo, S., Duan, K., Lum, J., et al. (2018). The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. Nature Communications, 9, 582-. doi: 10.1038/s41467-018-02834-8
Grant Information
Ministry of Education (MOE): Tier2 MOE2014-T2-1-011
Ministry of Education (MOE): Tier2 MOE2016-T2-1-012
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