Appointment: Associate Professor

Research topics:

• Ezh2 auto-methylation and its physiological implication
• Ezh2-regulated dendritic cell functions in health and disease
• The functional role of cytosolic lysine methylation in immune cells
• Functional Signifiance of the Ezh2-Vav1 Interaction in normal & tumor cells
• Functional significance of talin methylation in normal and tumor cells
• The role of Polycomb Group Protein Ezh2 in immune Response of Dendritic cells
• Transcriptional Regulation of Ezh2 Expression in Immune Cells and Lymphoma
• Understanding mammalian microRNA biology in health and disease

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11 to 18 of 18 Results
onc2017309x2.avi
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
AVI Video - 6.2 MB - MD5: a3a4922fd3570459139471192c4fb490
Data
Supplementary Video S1 (related to Figure 4) EZH2ΔNLS promotes adhesion turnover. The turnover of adhesion structures in EZH2 knockdown H16N2 cells overexpressing EZH2ΔNLS and mCherry-Paxillin was monitored by mCherry signals in time-lapse imaging.
onc2017309x3.avi
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
AVI Video - 7.4 MB - MD5: 06ecc4f6d3e874c24e5fb52c51e21bbd
Data
Supplementary Video 2 (related to Figure 4) VAV interaction mutant EZH2 prevents adhesion turnover. The turnover of adhesion structures in EZH2 knockdown H16N2 cells overexpressing VAV interaction mutant EZH2 (EZH2-VAV/MT) and mCherry-Paxillin was monitored by mCherry signals...
onc2017309x4.avi
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
AVI Video - 7.4 MB - MD5: fbcfb998aacce8ac2bd35035119d9d08
Data
Supplementary video 3 (related to Figure 5) Un-methylatable Talin1 contributes to extremely stable adhesion structures (Talin1-K2454Q). The turnover of adhesion structures in unmethylatable GFP-Talin1 (Talin1-K2454Q) overexpressing H16N2 cells was monitored by GFP signals in t...
onc2017309x5.avi
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
AVI Video - 7.4 MB - MD5: 13a7ed94429fb9bc1120eb3dbb8817c6
Data
Supplementary video 4 (related to Figure 5). Methyl-mimicking Talin1 promotes adhesion turnover. The turnover of adhesion structures in methyl-mimicking GFP-Talin1 (Talin1-K2454F) overexpressing H16N2 cells was monitored by GFP signals in time-lapse live imaging.
onc2017309x6.mp4
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
MPEG-4 Video - 3.1 MB - MD5: 9834879235ecf0907ff4af79f80b11f0
Data
Supplementary video 5 (related to Figure 8) 3D reconstruction of Z-stack confocal images of EZH2 expression in breast cancer stem cells (CD44hiSP). Sorted CD44hi Rhodamine 123low side population (SP) MDA-MB-231 cells were stained with anti-EZH2 specific antibody (green) and DA...
onc2017309x7.mp4
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
MPEG-4 Video - 2.8 MB - MD5: e7dfb4b06af4f207afa98665cab199d6
Data
Supplementary video 6 (related to Figure 8) 3D reconstruction of Z-stack confocal images of EZH2 expression in breast cancer cells (CD44low). Sorted CD44low Rhodamine 123hi MDA-MB-231 cells were stained with anti-EZH2 specific antibody (green) and DAPI (blue) for nuclei.
onc2017309x8.tab
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
Tabular Data - 185 B - 4 Variables, 5 Observations - UNF:6:Jip7WN9yR3MzhAn3KTokSQ==
Data
Source data for main figures in combined excel file
Supplementary-Figure and Legends-July2017-Final.pdf
Supplementary-Figure and Legends-July2017-Final.pdf
Dec 18, 2018 - Related Data for: EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
Adobe PDF - 5.6 MB - MD5: d68f60f31416e4eb1b3b4166d0628b94
Documentation
Legends for the supplementary data and files
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