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Guillaume Thibault (Nanyang Technological University)

Appointment: Assistant Professor

Research topics:

• Lipid Regulations in Eukaryotes

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1 to 4 of 4 Results
Nov 13, 2020
Thibault, Guillaume; Yap, Wei Sheng; Shuy, Peter Jr.; Marvalim, Charlie, 2020, "Replication Data for: The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis",, DR-NTU (Data), V2
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage inducing transmembrane (FIT) family induces LD formation. Here, we establish a model system to study the role of S. cerevisiae FIT homologues (ScFIT), SCS3 and YFT2, in proteosta...
Jun 18, 2020
Ho, Nurulain; Yap, Wei Sheng; Xu, Jiaming; Wu, Haoxi; Koh, Jhee Hong; George, Bhawana; Chong, Shu Chen; Taubert, Stefan; Guillaume Thibault, 2020, "Replication Data for: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress",, DR-NTU (Data), V1
Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised,...
May 27, 2020
Beaudoin-Chabot, Caroline; Lei, Wang; Shchepinov, Mikhail S.; Smarun, Alexey V.; Vidović, Drasko; Guillaume Thibault, 2020, "Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans",, DR-NTU (Data), V1, UNF:6:vX21yKAg/6svjOec2AP1IA== [fileUNF]
Chemically reinforced essential fatty acids promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essen...
May 27, 2020
Koh, Jhee Hong; Lei, Wang; Beaudoin-Chabot, Caroline; Thibault, Guilaume, 2020, "Replication Data for: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress",, DR-NTU (Data), V1
Metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), are emerging as epidemics that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Perturbation of endoplasmic reticulum (ER) homeostasis...
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