Guillaume Thibault

Appointment: Assistant Professor

Research topics:

• Lipid Regulations in Eukaryotes

For more information, visit webpage

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1 to 4 of 4 Results

Replication Data for: The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis Nov 13, 2020 Thibault, Guillaume; Yap, Wei Sheng; Shuy, Peter Jr.; Marvalim, Charlie, 2020, "Replication Data for: The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis", https://doi.org/10.21979/N9/I7MXVP, DR-NTU (Data), V2 Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage inducing transmembrane (FIT) family induces LD formation. Here, we establish a model system to study the role of S. cerevisiae FIT homologues (ScFIT), SCS3 and YFT2, in proteosta...
Replication Data for: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress Jun 18, 2020 Ho, Nurulain; Yap, Wei Sheng; Xu, Jiaming; Wu, Haoxi; Koh, Jhee Hong; George, Bhawana; Chong, Shu Chen; Taubert, Stefan; Guillaume Thibault, 2020, "Replication Data for: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress", https://doi.org/10.21979/N9/5BJD2Z, DR-NTU (Data), V1 Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised,...
Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans May 27, 2020 Beaudoin-Chabot, Caroline; Lei, Wang; Shchepinov, Mikhail S.; Smarun, Alexey V.; Vidović, Drasko; Guillaume Thibault, 2020, "Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans", https://doi.org/10.21979/N9/MGPD5H, DR-NTU (Data), V1, UNF:6:vX21yKAg/6svjOec2AP1IA== [fileUNF] Chemically reinforced essential fatty acids promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essen...
Replication Data for: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress May 27, 2020 Koh, Jhee Hong; Lei, Wang; Beaudoin-Chabot, Caroline; Thibault, Guilaume, 2020, "Replication Data for: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress", https://doi.org/10.21979/N9/OLY1FU, DR-NTU (Data), V1 Metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), are emerging as epidemics that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Perturbation of endoplasmic reticulum (ER) homeostasis...

Replication Data for: The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis

Nov 13, 2020

Thibault, Guillaume; Yap, Wei Sheng; Shuy, Peter Jr.; Marvalim, Charlie, 2020, "Replication Data for: The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis", https://doi.org/10.21979/N9/I7MXVP, DR-NTU (Data), V2

Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage inducing transmembrane (FIT) family induces LD formation. Here, we establish a model system to study the role of S. cerevisiae FIT homologues (ScFIT), SCS3 and YFT2, in proteosta...

Replication Data for: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Jun 18, 2020

Ho, Nurulain; Yap, Wei Sheng; Xu, Jiaming; Wu, Haoxi; Koh, Jhee Hong; George, Bhawana; Chong, Shu Chen; Taubert, Stefan; Guillaume Thibault, 2020, "Replication Data for: Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress", https://doi.org/10.21979/N9/5BJD2Z, DR-NTU (Data), V1

Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised,...

Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans

May 27, 2020

Beaudoin-Chabot, Caroline; Lei, Wang; Shchepinov, Mikhail S.; Smarun, Alexey V.; Vidović, Drasko; Guillaume Thibault, 2020, "Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans", https://doi.org/10.21979/N9/MGPD5H, DR-NTU (Data), V1, UNF:6:vX21yKAg/6svjOec2AP1IA== [fileUNF]

Chemically reinforced essential fatty acids promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essen...

Replication Data for: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

May 27, 2020

Koh, Jhee Hong; Lei, Wang; Beaudoin-Chabot, Caroline; Thibault, Guilaume, 2020, "Replication Data for: Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress", https://doi.org/10.21979/N9/OLY1FU, DR-NTU (Data), V1

Metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), are emerging as epidemics that affect the global population. One facet of these disorders is attributed to the disturbance of membrane lipid composition. Perturbation of endoplasmic reticulum (ER) homeostasis...

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