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Karen Carmelina Crasta (Nanyang Technological University)

Appointment: Associate Professor

Nanyang Associate Professor (NRF), Lee Kong Chian School of Medicine Principal Investigator

Research topics:

• Dissecting Aneuploidy-Induced Senescence and Inflammatory Signalling in Cancer

• Molecular Mechanisms That Dictate Cell Fate Following Treatment With Anti-Mitotic Drugs

• Molecular Mechanisms Underlying Soft Tissue Sarcoma Predisposition

• Start-Up Grant

• Students as Partners: Qualitative Analysis of Student Reflections in Practical Reports for Collaborative Curriculum Development

• The Mechanistic Role of Chromosomal Instability in HepatitisB Virus-induced Hepatocarcinogesis

• Understanding the functional consequences of DNA double-strand breaks in insulin-producing cells of diabetic mice and determining p21 as a cell fate regulator post-DNA damage during diabetes

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Jan 16, 2020
Crasta, Karen Carmelina, 2020, "Autophagy Governs Protumorigenic Effects of Mitotic Slippage-induced Senescence.", https://doi.org/10.21979/N9/TCIPKN, DR-NTU (Data), V1, UNF:6:tf/HCzlTuv2LWX3W5TJokw== [fileUNF]
The most commonly utilized class of chemotherapeutic agents administered as a first-line therapy are antimitotic drugs; however, their clinical success is often impeded by chemoresistance and disease relapse. Hence, a better understanding of the cellular pathways underlying escap...
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