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Part 1: Document Description
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Citation |
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Title: |
A Silk-Microneedle Patch to Detect Glucose in the Interstitial Fluid of Skin or Plant Tissue |
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Identification Number: |
doi:10.21979/N9/WYLCBJ |
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Distributor: |
DR-NTU (Data) |
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Date of Distribution: |
2023-11-01 |
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Version: |
2 |
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Bibliographic Citation: |
Zheng, Lewen; Zhu, Dan Dan; Wang, Wenjun; Liu, Jiyang; Thng, Steven Tien Guan; Chen, Peng, 2023, "A Silk-Microneedle Patch to Detect Glucose in the Interstitial Fluid of Skin or Plant Tissue", https://doi.org/10.21979/N9/WYLCBJ, DR-NTU (Data), V2 |
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Citation |
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Title: |
A Silk-Microneedle Patch to Detect Glucose in the Interstitial Fluid of Skin or Plant Tissue |
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Identification Number: |
doi:10.21979/N9/WYLCBJ |
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Authoring Entity: |
Zheng, Lewen (Nanyang Technological University) |
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Zhu, Dan Dan (Nanyang Technological University) |
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Wang, Wenjun (Liaocheng University) |
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Liu, Jiyang (Zhejiang Sci-Tech University) |
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Thng, Steven Tien Guan (Skin Research Institute of Singapore) |
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Chen, Peng (Nanyang Technological University) |
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Software used in Production: |
origin |
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Grant Number: |
RG110/20 |
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Grant Number: |
RT02/20 |
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Grant Number: |
2019-T2-2-004 |
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Distributor: |
DR-NTU (Data) |
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Access Authority: |
Zheng, Lewen |
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Depositor: |
Zheng, Lewen |
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Date of Deposit: |
2023-11-01 |
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Holdings Information: |
https://doi.org/10.21979/N9/WYLCBJ |
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Study Scope |
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Keywords: |
Chemistry, Engineering, Medicine, Health and Life Sciences, Chemistry, Engineering, Medicine, Health and Life Sciences, Microneedles, Glucose detection, Interstitial skin fluid, Electrochemistry |
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Abstract: |
Glucose is critical to all organisms. Herein, we developed a wire electrode embedded microneedle patch (WEMNP) for in situ real-time detection of glucose in the interstitial fluid (ISF) of skin or plant tissues with minimal invasiveness. WEMNP is made of proline treated silk fibroin proteins, which provide good mechanical strength (0.75 N/microneedle) for tissue penetration and desirable bioelectronic interface for fast and high-fidelity detection. WEMNP shows specific and linear response to glucose between 3 and 18 mM for detection in skin ISF with a sensitivity of 21.21 nA/mM and between 30 and 180 mM for detection in plant ISF with a sensitivity of 1.22 nA/mM. Such self-administrable WEMNP could be instrumental to long-term home-based management for chronic diseases and to smart agriculturing. |
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Kind of Data: |
experimental data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
10.1016/j.snb.2022.132626 |
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Bibliographic Citation: |
Zheng, L., Zhu, D., Wang, W., Liu, J., Thng, S. T. G., & Chen, P. (2022). A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue. Sensors and Actuators B: Chemical, 372, 132626. |
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Citation |
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Identification Number: |
10356/162771 |
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Bibliographic Citation: |
Zheng, L., Zhu, D., Wang, W., Liu, J., Thng, S. T. G., & Chen, P. (2022). A silk-microneedle patch to detect glucose in the interstitial fluid of skin or plant tissue. Sensors and Actuators B: Chemical, 372, 132626. |
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Label: |
Characterization of WEMNP.jpg |
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Notes: |
image/jpeg |
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Figure S1.jpg |
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image/jpeg |
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Figure S2.tif |
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image/tiff |
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Glucose detection in growing plants by WEMNP.tif |
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image/tiff |
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stability study.tif |
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image/tiff |
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The glucose sensing in skin ISF by WEMNPs.jpg |
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Notes: |
image/jpeg |