Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies (doi:10.21979/N9/VKPDCD)

View:

Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
Part 5: Other Study-Related Materials
Entire Codebook

Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies

doi:10.21979/N9/VKPDCD

DR-NTU (Data)

2019-09-20

1

Hoo, Regina May Ling, 2019, "Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies", https://doi.org/10.21979/N9/VKPDCD, DR-NTU (Data), V1, UNF:6:gWhTU82zoCivH8NbdrP3/Q== [fileUNF]

Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies

doi:10.21979/N9/VKPDCD

Hoo, Regina May Ling (Nanyang Technological University)

R

Academic Research Fund Tier 1 RG41/16

under its Individual Research Grant NMRC/1292/2011

DR-NTU (Data)

Hoo, Regina May Ling

Hoo, Regina May Ling

2019-09-20

https://doi.org/10.21979/N9/VKPDCD

Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, microarray, controlled-human malaria infection

Background The transcriptome of Plasmodium falciparum clinical isolates varies according to strain, mosquito bites, disease severity and clinical history. Therefore, it remains a challenge to directly interpret the parasite's transcriptomic information into a more general biological signature in a natural human malaria infection. These confounding variations can be potentially overcome with parasites derived from controlled-human malaria infection (CHMI) studies. Methods We performed CHMI studies in healthy and immunologically naïve volunteers receiving the same P. falciparum strain ((Sanaria® PfSPZ Challenge (NF54)), but with different sporozoite dosage and route of infection. Parasites isolated from these volunteers at the day of patency were subjected to in vitro culture for several generations and synchronized ring-stage parasites were subjected to transcriptome profiling. Findings We observed clear deviations between CHMI-derived parasites from volunteer groups receiving different PfSPZ dose and route. CHMI-derived parasites and the pre-mosquito strain used for PfSPZ generation showed significant transcriptional variability for gene clusters associated with malaria pathogenesis, immune evasion and transmission. These transcriptional variation signature clusters were also observed in the transcriptome of P. falciparum isolates from acute clinical infections. Interpretation Our work identifies a previously unrecognized transcriptional pattern in malaria infections in a non-immune background. Significant transcriptome heterogeneity exits between parasites derived from human infections and the pre-mosquito strain, implying that the malaria parasites undergo a change in functional state to adapt to its host environment. Our work also highlights the potential use of transcriptomics data from CHMI study advance our understanding of malaria parasite adaptation and transmission in humans.

experimental data

10.1016/j.ebiom.2019.09.001

Hoo, R., Bruske, E., Dimonte, S., Zhu, L., Mordmüller, B., Sim, B. K. L., ... & Preiser, P. R. (2019). Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies. EBioMedicine, 48, 442-452.

10356/143981

Hoo, R., Bruske, E., Dimonte, S., Zhu, L., Mordmüller, B., Sim, B. K. L., ... & Preiser, P. R. (2019). Transcriptome profiling reveals functional variation in Plasmodium falciparum parasites from controlled human malaria infection studies. EBioMedicine, 48, 442-452.

• Number of cases: 48

• No. of variables per record: 9

• Type of File: text/tab-separated-values

UNF:6:n8ddmbLGbIbJb5Kh9tItLg==

• Number of cases: 86

• No. of variables per record: 15

• Type of File: text/tab-separated-values

UNF:6:UiIvrWJ5g27najDhs23N7A==

• Number of cases: 1835

• No. of variables per record: 18

• Type of File: text/tab-separated-values

UNF:6:vc9pgLBXVgLRWCqsVFo9jA==

• Number of cases: 197

• No. of variables per record: 13

• Type of File: text/tab-separated-values

UNF:6:bAuMzVcuYHJuAlWO0Zy7Jg==

• Number of cases: 55

• No. of variables per record: 4

• Type of File: text/tab-separated-values

UNF:6:0nzS6w7tVW8he9s72apCFg==

• PathwayName - PathwayName
• Annotated - Annotated
• Drawn - Drawn
• AnnoinPathway - AnnoinPathway
• InputPathway - InputPathway
• Directionofdeviationfromexpected - Directionofdeviationfromexpected
• HypergeometricPvalue - HypergeometricPvalue
• BinomialPvalue - BinomialPvalue
• GeneList - GeneList
• A - A
• T1001.2500ID.13.5 - T1001.2500ID.13.5
• T1015.2500ID.13.5 - T1015.2500ID.13.5
• T1022.2500ID.13.5 - T1022.2500ID.13.5
• T1001.2500ID.15.5 - T1001.2500ID.15.5
• T1015.2500ID.15.5.rep. - T1015.2500ID.15.5.rep.
• T1022.2500ID.15.5 - T1022.2500ID.15.5
• T1018.3200IV.13.5 - T1018.3200IV.13.5
• T1043.3200IV.13.5 - T1043.3200IV.13.5
• T1045.3200IV.13.5 - T1045.3200IV.13.5
• T1039.3200IV.17 - T1039.3200IV.17
• T1040.3200IV.17.5 - T1040.3200IV.17.5
• T1043.3200IV.15 - T1043.3200IV.15
• pvalue - pvalue
• padjust(FDR) - padjust(FDR)
• geneID - geneID
• annotation - annotation
• NF54321.21 - NF54321.21
• NF5433.21 - NF5433.21
• T1001.2500ID.13.5 - T1001.2500ID.13.5
• T1015.2500ID.13.5 - T1015.2500ID.13.5
• T1022.2500ID.13.5 - T1022.2500ID.13.5
• T1001.2500ID.15.5 - T1001.2500ID.15.5
• T1015.2500ID.15.5.rep. - T1015.2500ID.15.5.rep.
• T1022.2500ID.15.5 - T1022.2500ID.15.5
• T1018.3200IV.13.5 - T1018.3200IV.13.5
• T1043.3200IV.13.5 - T1043.3200IV.13.5
• T1045.3200IV.13.5 - T1045.3200IV.13.5
• T1039.3200IV.17 - T1039.3200IV.17
• T1040.3200IV.17.5 - T1040.3200IV.17.5
• T1043.3200IV.15 - T1043.3200IV.15
• pvalue - pvalue
• padjust(FDR) - padjust(FDR)
• gene - gene
• annotation - annotation
• log2FoldChange(CHMI/PfNF54) - log2FoldChange(CHMI/PfNF54)
• pvalue - pvalue
• padjust(FDR) - padjust(FDR)
• variant - variant
• gametocyte - gametocyte
• transcription - transcription
• proteinturnover - proteinturnover
• metabolism - metabolism
• unknownfunction - unknownfunction
• structural - structural
• signaling - signaling
• SampleID - SampleID
• RNAconc(ng/ul) - RNAconc(ng/ul)
• A260/280 - A260/280
• A260/230 - A260/230

f15103 Location:

Variable Format: character

Notes: UNF:6:RFazZKRiM8F8Zg+KUibkKA==

f15103 Location:

Summary Statistics: Max. 3709.0; Min. 3709.0; StDev 0.0; Valid 48.0; Mean 3709.0;

Variable Format: numeric

Notes: UNF:6:LYpGq+yvxFt6cDBL7dQxEg==

f15103 Location:

Summary Statistics: Mean 629.0; Min. 629.0; StDev 0.0; Max. 629.0; Valid 48.0

Variable Format: numeric

Notes: UNF:6:97c0uBOfpEXqqCMzyYpbNg==

f15103 Location:

Summary Statistics: Min. 3.0; StDev 258.14839525286857; Valid 48.0; Max. 1222.0; Mean 127.45833333333329;

Variable Format: numeric

Notes: UNF:6:VgiUgh3PQMfdHr8HCg93RQ==

f15103 Location:

Summary Statistics: Max. 247.0; Mean 29.29166666666668; StDev 50.62879440293868; Valid 48.0; Min. 3.0

Variable Format: numeric

Notes: UNF:6:KS6/Y2wgCvVgJSQxM8PSvw==

f15103 Location:

Variable Format: character

Notes: UNF:6:rRCRaMMxyG6SIz6HywjFEw==

f15103 Location:

Summary Statistics: Min. 0.0; Mean 0.014451330936676221; StDev 0.013512920874796283; Valid 48.0; Max. 0.0483442642976943

Variable Format: numeric

Notes: UNF:6:SwARibs8JexCpbN6nOurPQ==

f15103 Location:

Summary Statistics: StDev 0.0419123039268803; Min. 2.53285463026185E-5; Mean 0.05093773335639957; Valid 48.0; Max. 0.148968566758084

Variable Format: numeric

Notes: UNF:6:anQCbMoNJYiEDFm42Yk7Zg==

f15103 Location:

Variable Format: character

Notes: UNF:6:V48tO75ioPCZOpYnLmtygw==

f15120 Location:

Variable Format: character

Notes: UNF:6:CptLvlleg6MzC9Iyz14UtQ==

f15120 Location:

Summary Statistics: StDev 0.7586225652686752; Max. 2.45034841; Min. -1.084734981; Mean 0.5509951309534883; Valid 86.0

Variable Format: numeric

Notes: UNF:6:ajCosXES+8Dtt7Dqn1oWGQ==

f15120 Location:

Summary Statistics: Mean 0.4869741303720931; Min. -0.941763808; StDev 0.7724695222889656; Max. 2.444730397; Valid 86.0;

Variable Format: numeric

Notes: UNF:6:zSvmXLzxwyB6QxO6DtVBcw==

f15120 Location:

Summary Statistics: Min. -0.825118012; StDev 0.7225311244670207; Mean 0.45267720501162784; Valid 86.0; Max. 2.515339581

Variable Format: numeric

Notes: UNF:6:FuFxUuy6vgfDACFkeFu3ag==

f15120 Location:

Summary Statistics: Mean 0.41524221689534885; Min. -1.361636427; Max. 2.36761864; StDev 0.7592451384187706; Valid 86.0

Variable Format: numeric

Notes: UNF:6:qOPYvcisn7/7eatnQwjhtw==

f15120 Location:

Summary Statistics: Min. -0.705965516; Max. 2.74151469; StDev 0.7769710465198486; Valid 86.0; Mean 0.5976151719999999

Variable Format: numeric

Notes: UNF:6:TUgRqnFgNT1Nw1PWnDJdKg==

f15120 Location:

Summary Statistics: Valid 86.0; Max. 2.928305047; Min. -0.899627443; StDev 0.7128108899988418; Mean 0.5030250696162791;

Variable Format: numeric

Notes: UNF:6:O4CfQm8tlqhqLF+50WUmPA==

f15120 Location:

Summary Statistics: Max. 2.082112081; Mean -0.034885408488372086; Valid 86.0; Min. -1.447732338; StDev 0.6772931412959852

Variable Format: numeric

Notes: UNF:6:yZ3KYpRnXafG+W3K3KbwYQ==

f15120 Location:

Summary Statistics: Valid 86.0; Max. 1.909358862; Mean 0.0890843845232558; Min. -1.004518956; StDev 0.5942323917457331;

Variable Format: numeric

Notes: UNF:6:HIKoW8W4l8Li3KibCFbwZA==

f15120 Location:

Summary Statistics: Valid 86.0; Min. -1.429458652; Mean -0.022470028174418614; Max. 1.807643756; StDev 0.6483685422202251

Variable Format: numeric

Notes: UNF:6:zUaMCXBkIYP8fWbHg1aX9g==

f15120 Location:

Summary Statistics: Mean 0.04777043366279071; Min. -1.082988314; Valid 86.0; Max. 1.693979717; StDev 0.5617983750559905

Variable Format: numeric

Notes: UNF:6:kKuvNl+UDZ8a36O/ELwFog==

f15120 Location:

Summary Statistics: Max. 1.824700426; Min. -1.478640609; Mean 0.07938657966279071; Valid 86.0; StDev 0.6918988304780485

Variable Format: numeric

Notes: UNF:6:CPpgYSOxptoaML+N1dG43g==

f15120 Location:

Summary Statistics: Max. 1.87692767; Valid 86.0; Min. -1.110635899; StDev 0.615371805619639; Mean 0.05624692775581392

Variable Format: numeric

Notes: UNF:6:2BRLj0SDtvkC6P/qQ6yqng==

f15120 Location:

Summary Statistics: StDev 0.009131783804519839; Mean 0.030160629085586112; Min. 0.00935156608; Max. 0.0496886474418605; Valid 86.0;

Variable Format: numeric

Notes: UNF:6:IXjhLT+iS2A4LRz0z5qgHQ==

f15120 Location:

Summary Statistics: Valid 86.0; StDev 3.1227784724084884E-4; Min. 3.26308E-6; Mean 4.083178276744186E-4; Max. 0.00113168;

Variable Format: numeric

Notes: UNF:6:LfLX71F9cr5PvZw4R1d3fA==

f15142 Location:

Variable Format: character

Notes: UNF:6:GGMrmXMhNgqyexLHxBpfRg==

f15142 Location:

Variable Format: character

Notes: UNF:6:yR83n1iTUdmPBTbkqNGBbQ==

f15142 Location:

Summary Statistics: Mean 0.04508692360817439; Min. -2.286912699; Max. 3.882398533; Valid 1835.0; StDev 0.8311433751562499

Variable Format: numeric

Notes: UNF:6:wPgurJ1xAORNub+k/8vOyA==

f15142 Location:

Summary Statistics: Min. -2.592218254; Mean 0.058141927519890994; Max. 3.477167079; Valid 1835.0; StDev 0.8354783268471383

Variable Format: numeric

Notes: UNF:6:Zu0fAD9TeAAwjSAN2PXrbA==

f15142 Location:

Summary Statistics: Min. -2.959842495; StDev 0.8570224342555798; Max. 3.295059948; Mean 0.08226320393460494; Valid 1835.0

Variable Format: numeric

Notes: UNF:6:n4QKYs/cJVNom7sKfpryEQ==

f15142 Location:

Summary Statistics: Valid 1835.0; Min. -2.740178807; StDev 0.827170959897346; Mean 0.05647785503215259; Max. 3.557227477;

Variable Format: numeric

Notes: UNF:6:3dpyvK0Hi6GPN3ayQfY2LA==

f15142 Location:

Summary Statistics: StDev 0.7288468914518282; Valid 1835.0; Mean 0.044204231969482276; Min. -2.33277629; Max. 4.240492274

Variable Format: numeric

Notes: UNF:6:RlFHdATQUo4DvfBHlKdlcA==

f15142 Location:

Summary Statistics: Mean 0.09498659559128068; StDev 0.952895153972239; Max. 4.113797514; Min. -3.110998515; Valid 1835.0

Variable Format: numeric

Notes: UNF:6:GQm2xXhzfO9y+kTrSccNaA==

f15142 Location:

Summary Statistics: Min. -2.956126914; Valid 1835.0; StDev 0.9094872983129455; Max. 3.621384169; Mean 0.14157699145504088

Variable Format: numeric

Notes: UNF:6:CBLo8KUy7imo2HzxNW5rfA==

f15142 Location:

Summary Statistics: Min. -3.359576555; Max. 3.354135844; Mean 0.10435593550190736; Valid 1835.0; StDev 0.8051892026847293;

Variable Format: numeric

Notes: UNF:6:idJqYdnD476pR4OS58lKYA==

f15142 Location:

Summary Statistics: Valid 1835.0; Mean 0.0716086255455041; Min. -3.083203324; Max. 2.700483515; StDev 0.7887161863172744

Variable Format: numeric

Notes: UNF:6:Mwa+JYiNzOgAg3MAPemfkw==

f15142 Location:

Summary Statistics: Valid 1835.0; Mean 0.08073290112970027; Max. 2.833046723; StDev 0.6908050353477789; Min. -2.466238152;

Variable Format: numeric

Notes: UNF:6:h8pQwkRcAcP5yToJbZY30w==

f15142 Location:

Summary Statistics: Max. 2.925696035; StDev 0.6835211789476743; Mean 0.03160259696294279; Valid 1835.0; Min. -2.656743246

Variable Format: numeric

Notes: UNF:6:vaRXDknDtGnH7LfV6J9Xvg==

f15142 Location:

Summary Statistics: Mean 0.060587381664850115; Max. 3.402345134; Valid 1835.0; StDev 0.7624217849579773; Min. -2.984157551;

Variable Format: numeric

Notes: UNF:6:YfzE9RBxpuDe38rmJG+/Gg==

f15142 Location:

Summary Statistics: Valid 1835.0; Mean 0.07764084429645783; Max. 3.192902275; StDev 0.9046001674875707; Min. -3.038092569

Variable Format: numeric

Notes: UNF:6:fNqy33kwajKxkn0mm3RM8Q==

f15142 Location:

Summary Statistics: Min. -2.589563436; Valid 1835.0; Max. 3.697449977; StDev 0.7929565450623254; Mean -0.007062091894277931

Variable Format: numeric

Notes: UNF:6:ZtlJOgClVIJexGxunFGpvw==

f15142 Location:

Summary Statistics: Min. 1.91566E-9; Valid 1835.0; Max. 0.999902787; StDev 0.2957409357922058; Mean 0.3159946601554551;

Variable Format: numeric

Notes: UNF:6:/CzVC64RdLEayiMK7u1gJg==

f15142 Location:

Summary Statistics: Max. 0.999902787; Mean 0.46177847459686244; StDev 0.2947565607908; Min. 3.5152361E-6; Valid 1835.0

Variable Format: numeric

Notes: UNF:6:Tm5z5BwpjoTNuNZOyjgPmg==

f15115 Location:

Variable Format: character

Notes: UNF:6:4X1oJ2DSx7QufHPNTNNRCw==

f15115 Location:

Variable Format: character

Notes: UNF:6:0vm/iYoyR5nJNQqluC5OaQ==

f15115 Location:

Summary Statistics: StDev 0.6726031141034684; Valid 197.0; Min. -1.3429162552395204; Max. 1.5540320972632158; Mean 0.09136304928089407

Variable Format: numeric

Notes: UNF:6:VAeRa6h12Y8eQuuNMuyGOg==

f15115 Location:

Summary Statistics: StDev 0.001531711989424618; Mean 0.0014567190304977343; Max. 0.005265899943733171; Min. 1.915657952660683E-9; Valid 197.0

Variable Format: numeric

Notes: UNF:6:4V4DYzEQJzNktkpluXyXrQ==

f15115 Location:

Summary Statistics: Min. 3.5152361E-6; Mean 0.018661677715628523; StDev 0.014716886093392934; Valid 197.0; Max. 0.0490503883248731

Variable Format: numeric

Notes: UNF:6:W+AgctZMFauCmja0Hr8J0A==

f15115 Location:

Summary Statistics: Max. NaN; Mean NaN; Min. NaN; StDev NaN; Valid 0.0

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: Mean NaN; Valid 0.0; StDev NaN; Min. NaN; Max. NaN

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: Mean NaN; Min. NaN; StDev NaN; Valid 0.0; Max. NaN;

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: Max. NaN; Valid 0.0; Mean NaN; Min. NaN; StDev NaN;

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: Max. NaN; StDev NaN; Valid 0.0; Mean NaN; Min. NaN

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: StDev NaN; Mean NaN; Min. NaN; Valid 0.0; Max. NaN

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: Max. NaN; Valid 0.0; Min. NaN; StDev NaN; Mean NaN

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15115 Location:

Summary Statistics: Min. NaN; Valid 0.0; StDev NaN; Max. NaN; Mean NaN;

Variable Format: numeric

Notes: UNF:6:H//pD+IO2l0mORpd7h2HzA==

f15119 Location:

Variable Format: character

Notes: UNF:6:tJPIoppT+1bXOdR1tgx9Ig==

f15119 Location:

Variable Format: character

Notes: UNF:6:ZdsETy2zCfOY8bkoMtSLpQ==

f15119 Location:

Summary Statistics: StDev 0.13712414194090805; Mean 1.8845454545454545; Valid 55.0; Max. 2.42; Min. 1.63;

Variable Format: numeric

Notes: UNF:6:Lx052PtoH2Ndkt+7uR8Lxw==

f15119 Location:

Summary Statistics: Valid 55.0; Mean 0.42963636363636365; Max. 1.33; Min. 0.1; StDev 0.31609869319309736;

Variable Format: numeric

Notes: UNF:6:Bc3sNb3stAjyA0xh7Q1TyQ==

Label:

Fig.1.tif

image/tiff

Label:

Fig.2.tif

image/tiff

Label:

Fig.3.tif

image/tiff

Label:

matrix.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

metadata.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

NF54_32_1-21.gpr

application/octet-stream

Label:

NF54_32_2-22.5.gpr

application/octet-stream

Label:

NF54_33-21.gpr

application/octet-stream

Label:

Supplementary.Fig1.tif

image/tiff

Label:

Supplementary.Fig2.tif

image/tiff

Label:

Supplementary.Fig3.tif

image/tiff

Label:

Supplementary.Fig4.tif

image/tiff

Label:

Supplementary.Fig5.tif

image/tiff

Label:

Supplementary Table 1.xlsx

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Label:

T1001.2500ID.13.5.gpr

application/octet-stream

Label:

T1001.2500ID.15.5.gpr

application/octet-stream

Label:

T1001.2500ID.22.5.gpr

application/octet-stream

Label:

T1001.2500ID.45.gpr

application/octet-stream

Label:

T1015.2500ID.13.5.gpr

application/octet-stream

Label:

T1015.2500ID.15.5(rep).gpr

application/octet-stream

Label:

T1015.2500ID.17.gpr

application/octet-stream

Label:

T1015.2500ID.45.gpr

application/octet-stream

Label:

T1018.3200IV.13.5.gpr

application/octet-stream

Label:

T1018.3200IV.15.gpr

application/octet-stream

Label:

T1018.3200IV.22.gpr

application/octet-stream

Label:

T1018.3200IV.42.5.gpr

application/octet-stream

Label:

T1022.2500ID.13.5.gpr

application/octet-stream

Label:

T1022.2500ID.15.5.gpr

application/octet-stream

Label:

T1022.2500ID.17.gpr

application/octet-stream

Label:

T1022.2500ID.45.gpr

application/octet-stream

Label:

T1027.800IV.14.5.gpr

application/octet-stream

Label:

T1027.800IV.18(rep).gpr

application/octet-stream

Label:

T1027.800IV.21.gpr

application/octet-stream

Label:

T1027.800IV.44.5.gpr

application/octet-stream

Label:

T1028.800IV.12.5.gpr

application/octet-stream

Label:

T1028.800IV.14.5.gpr

application/octet-stream

Label:

T1028.800IV.16.gpr

application/octet-stream

Label:

T1028.800IV.44.5.gpr

application/octet-stream

Label:

T1034.800IV.12.5.gpr

application/octet-stream

Label:

T1034.800IV.14.5.gpr

application/octet-stream

Label:

T1034.800IV.20.gpr

application/octet-stream

Label:

T1034.800IV.44.5.gpr

application/octet-stream

Label:

T1039.3200IV.16.gpr

application/octet-stream

Label:

T1039.3200IV.17.gpr

application/octet-stream

Label:

T1039.3200IV.23.gpr

application/octet-stream

Label:

T1039.3200IV.45.gpr

application/octet-stream

Label:

T1040.3200IV.16.gpr

application/octet-stream

Label:

T1040.3200IV.17.5.gpr

application/octet-stream

Label:

T1040.3200IV.23.gpr

application/octet-stream

Label:

T1040.3200IV.45.gpr

application/octet-stream

Label:

T1041.3200IV.13.5.gpr

application/octet-stream

Label:

T1041.3200IV.15.gpr

application/octet-stream

Label:

T1041.3200IV.18.5.gpr

application/octet-stream

Label:

T1041.3200IV.42.5.gpr

application/octet-stream

Label:

T1043.3200IV.13.5.gpr

application/octet-stream

Label:

T1043.3200IV.15.gpr

application/octet-stream

Label:

T1043.3200IV.22.gpr

application/octet-stream

Label:

T1043.3200IV.41.gpr

application/octet-stream

Label:

T1044.3200IV.13.5.gpr

application/octet-stream

Label:

T1044.3200IV.15.gpr

application/octet-stream

Label:

T1044.3200IV.18.5.gpr

application/octet-stream

Label:

T1044.3200IV.41.gpr

application/octet-stream

Label:

T1045.3200IV.13.5.gpr

application/octet-stream

Label:

T1045.3200IV.15.gpr

application/octet-stream

Label:

T1045.3200IV.20.5.gpr

application/octet-stream

Label:

T1045.3200IV.41.gpr

application/octet-stream