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Part 1: Document Description
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Citation |
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Title: |
Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions |
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Identification Number: |
doi:10.21979/N9/XBXJPP |
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Distributor: |
DR-NTU (Data) |
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Date of Distribution: |
2021-10-19 |
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Version: |
1 |
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Bibliographic Citation: |
Chen, Qi; Nair, Sajith Kumar; Ruedl, Christiane, 2021, "Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions", https://doi.org/10.21979/N9/XBXJPP, DR-NTU (Data), V1 |
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Citation |
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Title: |
Microbiota regulates the turnover kinetics of intestinal macrophages under steady-state and inflammatory conditions |
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Identification Number: |
doi:10.21979/N9/XBXJPP |
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Authoring Entity: |
Chen, Qi (Nanyang Technological University) |
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Nair, Sajith Kumar (Nanyang Technological University) |
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Ruedl, Christiane (Nanyang Technological University) |
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Software used in Production: |
Flowjo |
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Grant Number: |
Tier 1 grant (RG35/18) |
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Distributor: |
DR-NTU (Data) |
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Access Authority: |
Ruedl, Christiane |
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Depositor: |
Ruedl, Christiane |
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Date of Deposit: |
2021-07-26 |
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Holdings Information: |
https://doi.org/10.21979/N9/XBXJPP |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, tissue-resident macrophages, germ-free, turnover kinetics, gut, microbiome, monocyte-dependent replenishment, inflammation, homeostasis |
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Abstract: |
The gut immune system has evolved to co-exist in a mutually beneficial symbiotic relationship with its microflora. Here, using a germ-free fate-mapping mouse model, we provide clear insight into how the enteric commensals determine the kinetics of macrophage turnover. The microbiome density along the gastrointestinal tract defines the persistence of ontogenically diverse macrophages, with the highest numbers of the long-lived F4/80hiTim4+ macrophage subset in the less densely colonized small intestine. Furthermore, the microbiome contributes to a tightly regulated monocyte-dependent replenishment of both long- and short-lived F4/80hi macrophages under homeostatic and inflammatory conditions. In the latter situation, the commensals regulate rapid replenishment of the depleted macrophage niche caused by the intestinal inflammation. The microbial ecosystem imprints a favorable cytokine microenvironment in the intestine to support macrophage survival and monocyte-dependent replenishment. Therefore, the host immune system-commensal cross-talk provides an efficient strategy to assure intestinal homeostasis. |
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Kind of Data: |
Experimental data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
10.26508/lsa.202101178 |
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Bibliographic Citation: |
Chen, Q., Nair, S. & Ruedl, C. (2022). Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation. Life Science Alliance, 5(1), e202101178-. |
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Citation |
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Identification Number: |
10356/159288 |
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Bibliographic Citation: |
Chen, Q., Nair, S. & Ruedl, C. (2022). Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation. Life Science Alliance, 5(1), e202101178-. |
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Label: |
Figure 1.zip |
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Notes: |
application/zip |
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Label: |
Figure 2.zip |
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Notes: |
application/zip |
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Label: |
Figure 3.zip |
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Notes: |
application/zip |
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Label: |
Figure 5.zip |
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Notes: |
application/zip |