Related Data for: Defining a critical period for inhibitory circuits within the somatosensory cortex (doi:10.21979/N9/HXXSEY)

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Part 1: Document Description
Part 2: Study Description
Part 3: Data Files Description
Part 4: Variable Description
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Document Description

Citation

Title:

Related Data for: Defining a critical period for inhibitory circuits within the somatosensory cortex

Identification Number:

doi:10.21979/N9/HXXSEY

Distributor:

DR-NTU (Data)

Date of Distribution:

2018-04-23

Version:

1

Bibliographic Citation:

Lo, Shun Qiang; Sng, Judy C.G; Augustine, George J, 2018, "Related Data for: Defining a critical period for inhibitory circuits within the somatosensory cortex", https://doi.org/10.21979/N9/HXXSEY, DR-NTU (Data), V1, UNF:6:iuO4LDx6HcL7zzboVntPmg== [fileUNF]

Study Description

Citation

Title:

Related Data for: Defining a critical period for inhibitory circuits within the somatosensory cortex

Identification Number:

doi:10.21979/N9/HXXSEY

Authoring Entity:

Lo, Shun Qiang (Nanyang Technological University)

Sng, Judy C.G (National University of Singapore)

Augustine, George J (Nanyang Technological University)

Software used in Production:

Matlab

Grant Number:

2008 NRFCRP 002-082

Distributor:

DR-NTU (Data)

Access Authority:

Augustine, George J

Depositor:

Teo, Ying Ching

Date of Deposit:

2018-02-06

Holdings Information:

https://doi.org/10.21979/N9/HXXSEY

Study Scope

Keywords:

Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, somatosensory cortex, parvalbumin, interneurons, pyramidal cells, inhibitory circuit

Abstract:

Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit.

Kind of Data:

Experimental Data

Notes:

The manuscript has been accepted by Scientific Reports on June 2017.

Methodology and Processing

Sources Statement

Data Access

Other Study Description Materials

Related Publications

Citation

Identification Number:

10.1038/s41598-017-07400-8

Bibliographic Citation:

Lo, S. Q., Sng, J. C. G., & Augustine, G. J. (2017). Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports, 7(1), 7271-.

Citation

Identification Number:

10356/89605

Bibliographic Citation:

Lo, S. Q., Sng, J. C. G., & Augustine, G. J. (2017). Defining a critical period for inhibitory circuits within the somatosensory cortex. Scientific Reports, 7(1), 7271-.

File Description--f2413

File: SR data.tab

  • Number of cases: 9

  • No. of variables per record: 9

  • Type of File: text/tab-separated-values

Notes:

UNF:6:iuO4LDx6HcL7zzboVntPmg==

Variable Description

List of Variables:
  • A - A
  • B - B
  • Figure2b - Figure2b
  • D - D
  • E - E
  • F - F
  • G - G
  • H - H
  • I - I

Variables

A

f2413 Location:

Summary Statistics: Valid 0.0; Mean NaN; Min. NaN; Max. NaN; StDev NaN

Variable Format: numeric

Notes: UNF:6:6kmqn29s8tU9RU5ii6WjOQ==

B

f2413 Location:

Summary Statistics: Min. NaN; StDev NaN; Valid 0.0; Mean NaN; Max. NaN

Variable Format: numeric

Notes: UNF:6:6kmqn29s8tU9RU5ii6WjOQ==

Figure2b

f2413 Location:

Summary Statistics: Min. NaN; Mean NaN; StDev NaN; Valid 0.0; Max. NaN;

Variable Format: numeric

Notes: UNF:6:6kmqn29s8tU9RU5ii6WjOQ==

D

f2413 Location:

Variable Format: character

Notes: UNF:6:Rikg7xzhDqHDqBZZS6cyUw==

E

f2413 Location:

Variable Format: character

Notes: UNF:6:grW93Effs4JRTjQeGXIg5Q==

F

f2413 Location:

Variable Format: character

Notes: UNF:6:XC4QT5Msknc0izuAS6tzvw==

G

f2413 Location:

Summary Statistics: Mean NaN; StDev NaN; Valid 0.0; Min. NaN; Max. NaN

Variable Format: numeric

Notes: UNF:6:6kmqn29s8tU9RU5ii6WjOQ==

H

f2413 Location:

Variable Format: character

Notes: UNF:6:4GMS4ROcNbMHbYpcxGLnkA==

I

f2413 Location:

Variable Format: character

Notes: UNF:6:Oycf639QCeaeha/gknjwpg==