{"dcterms:modified":"2023-07-19","dcterms:creator":"DR-NTU (Data)","@type":"ore:ResourceMap","@id":"https://researchdata.ntu.edu.sg/api/datasets/export?exporter=OAI_ORE&persistentId=doi:10.21979/N9/EQXCRF","ore:describes":{"citation:depositor":"Ruedl Christiane","title":"Replication Data for: The tumour  microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.","kindOfData":"Experimental data","subject":"Medicine, Health and Life Sciences","dateOfDeposit":"2017-12-20","citation:keyword":{"citation:keywordValue":"Tissue-resident macrophages, Self-renewal, Lamina Propria, Colorectal cancer"},"software":{"citation:softwareName":"Flow Cytometry files (.fcs) obtained with BD Fortessa 5-laser flow cytometer (BD Bioscience). Data to be analysed using a FlowJo software (TreeStar, Ashland, OR, USA)"},"citation:dsDescription":{"citation:dsDescriptionValue":"Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that, a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80hi cells. In colon adenomas of ApcMin/+ mice, F4/80hiMHCIIlow macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, pro-tumoural F4/80hiMHCIIlow and F4/80hiMHCIIhi subpopulations can self-renew in the tumour and maintain their numbers mostly independently of a bone marrow contribution. In summary, the tumour microenvironment creates an isolated niche for tissue-resident macrophages that favours macrophage survival and self-renewal."},"citation:datasetContact":{"citation:datasetContactName":"Christiane Ruedl","citation:datasetContactAffiliation":"School of Biological Sciences, Nanyang Technological University"},"citation:topicClassification":{"citation:topicClassValue":"Cellular Immunology, Cancer Immunology, Ontogeny"},"publication":[{"publicationCitation":"Soncin, I., Sheng, J., Chen, Q., Foo, S., Duan, K., Lum, J., et al. (2018). The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. Nature Communications, 9, 582-.","publicationIDType":"doi","publicationIDNumber":"10.1038/s41467-018-02834-8","publicationURL":"https://www.nature.com/articles/s41467-018-02834-8"},{"publicationCitation":"Soncin, I., Sheng, J., Chen, Q., Foo, S., Duan, K., Lum, J., et al. (2018). The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. Nature Communications, 9, 582-.","publicationIDType":"handle","publicationIDNumber":"10356/89512","publicationURL":"https://hdl.handle.net/10356/89512"}],"grantNumber":[{"citation:grantNumberAgency":"Ministry of Education (MOE)","citation:grantNumberValue":"Tier2 MOE2014-T2-1-011"},{"citation:grantNumberAgency":"Ministry of Education (MOE)","citation:grantNumberValue":"Tier2 MOE2016-T2-1-012"}],"author":[{"citation:authorName":"Soncin, Irene","citation:authorAffiliation":"School of Biological Sciences, Nanyang Techological University, Nanyang Technological University"},{"citation:authorName":"Sheng, Jianpeng","citation:authorAffiliation":"School of Biological Sciences, Nanyang Technological University"},{"citation:authorName":"Chen, Qi","citation:authorAffiliation":"School of Biological Sciences, Nanyang Technological University"},{"citation:authorName":"Foo, Shihui","citation:authorAffiliation":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR)"},{"citation:authorName":"Duan, Kaibo","citation:authorAffiliation":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR)"},{"citation:authorName":"Lum, Josephine","citation:authorAffiliation":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR)"},{"citation:authorName":"Poidinger, Michael","citation:authorAffiliation":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR)"},{"citation:authorName":"Zolezzi, Francesca","citation:authorAffiliation":"Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR)"},{"citation:authorName":"Karjalainen, Klaus","citation:authorAffiliation":"School of Biological Sciences, Nanyang Technological University"},{"citation:authorName":"Ruedl, Christiane","citation:authorAffiliation":"School of Biological Sciences, Nanyang Technological University"}],"@id":"doi:10.21979/N9/EQXCRF","@type":["ore:Aggregation","schema:Dataset"],"schema:version":"1.2","schema:name":"Replication Data for: The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.","schema:dateModified":"Wed Aug 21 14:26:53 SGT 2019","schema:datePublished":"2017-12-20","schema:license":"http://creativecommons.org/licenses/by-nc/4.0","dvcore:fileTermsOfAccess":{"dvcore:fileRequestAccess":false},"schema:includedInDataCatalog":"DR-NTU (Data)","ore:aggregates":[{"schema:description":"The file contains .fcs files of the tumour samples in Fig. 1 ","schema:name":"Fig. 1 part 1 - tumour.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2009","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2009","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":929824838,"dvcore:storageIdentifier":"file://1603e5408d1-6736f9c438d7","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"f2fce78207add61dc9af289b50492147"}},{"schema:description":"The file contains the .fcs files of Lamina Propria samples in Fig. 1","schema:name":"Fig. 1 part 2 - LP.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2010","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2010","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":298773490,"dvcore:storageIdentifier":"file://1603e5725a7-e3dc9078da6c","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"83bd99a666cc8721c4395a0e72e8c9ca"}},{"schema:description":"The file contains the .fcs files in Fig. 2 panel A and Fig. 2 panel B","schema:name":"Fig. 2 part 1 - A, B.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2011","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2011","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":1398794293,"dvcore:storageIdentifier":"file://1603e5e0e84-f283f2c8896f","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"1573f388aa4db6fa6616ec035306dc0b"}},{"schema:description":"The file contains the .fcs files in Fig. 2 panel C","schema:name":"Fig. 2 part 2 - C.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2012","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2012","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":349577032,"dvcore:storageIdentifier":"file://1603e610edc-e87d4c48e0fe","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"f97ae753dd42a3f62ffe189622dc7ab5"}},{"schema:description":"The file contains the .fcs files in Fig. 3 panel A","schema:name":"Fig. 3 part 1 - A.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2013","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2013","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":138933378,"dvcore:storageIdentifier":"file://1603e62d0c1-83e2d5f8f668","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"2db9cd66cc026dde20e8aa3b38ab7fe4"}},{"schema:description":"The file contains the .fcs files in Fig. 3 panel B","schema:name":"Fig. 3 part 2 - B.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2014","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2014","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":567345885,"dvcore:storageIdentifier":"file://1603e6628ab-1afbaa450323","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"5fc9eebcff7766c70abfba1c584ac0fb"}},{"schema:description":"The file contains .fcs files in Fig. 3 panel C","schema:name":"Fig. 3 part 3 - C.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2015","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2015","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":814374869,"dvcore:storageIdentifier":"file://1603e7638b6-cabb085c1b23","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"c1396e887a94a36bb3a91ba519b961d8"}},{"schema:description":"The file contains .fcs files in Fig. 4 (part 1)","schema:name":"Fig. 4 part 1.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2016","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2016","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":1090039673,"dvcore:storageIdentifier":"file://1603ea59cec-f8153dc58f10","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"e6a39044ce4e194c3c7f76479104ae6e"}},{"schema:description":"The file contains .fcs files in Fig. 4 (part 2)","schema:name":"Fig. 4 part 2.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2017","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2017","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":488305320,"dvcore:storageIdentifier":"file://1603eafe6ac-31cb77d9cd67","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"36a3abab7ab90748eaf513267b0e3efa"}},{"schema:description":"The file contains .fcs files in Fig. 5 panel A (part 1)","schema:name":"Fig. 5 part 1 -A.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2018","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2018","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":957441925,"dvcore:storageIdentifier":"file://1603ec62da7-76a39b753849","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"f6c4d6b5f8000b26a9e9b2d13df3e243"}},{"schema:description":"The file contains .fcs files in Fig. 5 panel A (part2)","schema:name":"Fig 5 part 2 - A.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2019","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2019","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":883549563,"dvcore:storageIdentifier":"file://1603ed06c01-4009d134298e","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"3faabf7d070dca1374ae0facfc77da98"}},{"schema:description":"The file contains .fcs files in Fig. 5 panel B","schema:name":"Fig. 5 part 3 - B.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2020","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2020","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":525189085,"dvcore:storageIdentifier":"file://1603ed56024-699d5dbb84c6","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"92b72f0aa09266decaf17e1dc353a845"}},{"schema:description":"The file contains .fcs files in Fig. 6","schema:name":"Fig. 6.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2021","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2021","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":322071140,"dvcore:storageIdentifier":"file://1603ed83a9a-2000581a837c","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"892cf10ed32e40b18f6a8470e624990a"}},{"schema:description":"The file contains .fcs files in Fig. 7","schema:name":"Fig. 7.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2022","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2022","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":1191695280,"dvcore:storageIdentifier":"file://1603edfe60d-c64b4737e6ca","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"6ff563c33529ec943ee141597af86117"}},{"schema:description":"The file contains .fcs files in Supplementary Fig. 1","schema:name":"Suppl. Fig 1.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2023","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2023","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":420965953,"dvcore:storageIdentifier":"file://1603ee2a7df-ab8b38bf1d22","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"47c96f2674ca6967d4c3f361f36ea46d"}},{"schema:description":"The file contains .fcs files in Supplementary Fig. 2","schema:name":"Suppl. Fig 2.zip","dvcore:restricted":false,"schema:version":1,"dvcore:datasetVersionId":1146,"@id":"https://researchdata.ntu.edu.sg/file.xhtml?fileId=2024","schema:sameAs":"https://researchdata.ntu.edu.sg/api/access/datafile/2024","@type":"ore:AggregatedResource","schema:fileFormat":"application/zip","dvcore:filesize":593298059,"dvcore:storageIdentifier":"file://1603ee5ffab-97e289658d75","dvcore:rootDataFileId":-1,"dvcore:checksum":{"@type":"MD5","@value":"873b5f6b54123c4ba75a1305be4f0662"}}],"schema:hasPart":["https://researchdata.ntu.edu.sg/file.xhtml?fileId=2009","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2010","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2011","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2012","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2013","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2014","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2015","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2016","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2017","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2018","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2019","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2020","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2021","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2022","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2023","https://researchdata.ntu.edu.sg/file.xhtml?fileId=2024"]},"@context":{"author":"http://purl.org/dc/terms/creator","citation":"https://dataverse.org/schema/citation/","dateOfDeposit":"http://purl.org/dc/terms/dateSubmitted","dcterms":"http://purl.org/dc/terms/","dvcore":"https://dataverse.org/schema/core#","grantNumber":"https://schema.org/sponsor","kindOfData":"http://rdf-vocabulary.ddialliance.org/discovery#kindOfData","ore":"http://www.openarchives.org/ore/terms/","publication":"http://purl.org/dc/terms/isReferencedBy","publicationCitation":"http://purl.org/dc/terms/bibliographicCitation","publicationIDNumber":"http://purl.org/spar/datacite/ResourceIdentifier","publicationIDType":"http://purl.org/spar/datacite/ResourceIdentifierScheme","publicationURL":"https://schema.org/distribution","schema":"http://schema.org/","software":"https://www.w3.org/TR/prov-o/#wasGeneratedBy","subject":"http://purl.org/dc/terms/subject","title":"http://purl.org/dc/terms/title"}}