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Part 1: Document Description
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Citation |
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Title: |
Replication data for: Magnetically responsive peptide coacervates for dual hyperthermia and chemotherapy treatments of liver cancer |
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Identification Number: |
doi:10.21979/N9/Y7CAS3 |
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Distributor: |
DR-NTU (Data) |
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Date of Distribution: |
2020-05-12 |
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Version: |
1 |
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Bibliographic Citation: |
Lim, Zhi Wei; Vijaykumar B. Varma; R. V. Ramanujan; Ali Miserez, 2020, "Replication data for: Magnetically responsive peptide coacervates for dual hyperthermia and chemotherapy treatments of liver cancer", https://doi.org/10.21979/N9/Y7CAS3, DR-NTU (Data), V1, UNF:6:CgWydUb+URiN2s1BBJxPHw== [fileUNF] |
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Citation |
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Title: |
Replication data for: Magnetically responsive peptide coacervates for dual hyperthermia and chemotherapy treatments of liver cancer |
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Identification Number: |
doi:10.21979/N9/Y7CAS3 |
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Authoring Entity: |
Lim, Zhi Wei (Nanyang Technological University) |
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Vijaykumar B. Varma (Nanyang Technological University) |
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R. V. Ramanujan (Nanyang Technological University) |
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Ali Miserez (Nanyang Technological University) |
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Software used in Production: |
origin |
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Software used in Production: |
Zen Blue edition |
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Software used in Production: |
illustrator CS6 |
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Grant Number: |
Academic Research Fund Tier 2 grant MOE2015-T2-1-062 |
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Grant Number: |
Financial support from the Strategic Initiative on Biomimetic and Sustainable Materials (IBSM) |
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Distributor: |
DR-NTU (Data) |
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Access Authority: |
Lim, Zhi Wei |
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Depositor: |
Lim, Zhi Wei |
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Date of Deposit: |
2020-05-12 |
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Holdings Information: |
https://doi.org/10.21979/N9/Y7CAS3 |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, Doxorubicin loaded magnetic coacervates |
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Abstract: |
Liver cancer is an aggressive malignancy associated with high levels of mortality and morbidity. Doxorubicin (Dox) is often used to slow down liver cancer progression; however its efficacy is limited, and its severe side effects prevent its routine use at therapeutic concentrations. We present a biomimetic peptide that coacervates into micro-droplets, within which both Dox and magnetic nanoparticles (MNPs) can be sequestered. These Dox-loaded Magnetic Coacervates (DMCs) can be used for thermo-chemotherapy, with the controlled release of Dox triggered by an external Alternating Magnetic Field (AMF). The DMCs are internalized by the cells via an energy-independent mechanism which is not based on endocytosis. Application of AMF generates a temperature of 45 °C within the DMCs, triggering their disassembly and the simultaneous release of Dox, thereby resulting in dual hyperthermia and chemotherapy for more efficient cancer therapy. In vitro studies conducted under AMF reveal that DMCs are cytocompatible and effective in inducing HepG2 liver cancer cell death. Thermo-chemotherapy treatment against HepG2 cells is also shown to be more effective compared to either hyperthermia or chemotherapy treatments alone. Thus, our novel peptide DMCs can open avenues in theranostic strategies against liver cancer through programmable, wireless, and remote control of Dox release. |
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Country: |
Singapore |
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Kind of Data: |
images, graphs and illustrations |
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Notes: |
Paper has been accepted |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
10.1016/j.actbio.2020.04.024 |
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Bibliographic Citation: |
Lim, Z. W., Varma, V. B., Ramanujan, R. V., & Miserez, A. (2020). Magnetically Responsive Peptide Coacervates for Dual Hyperthermia and Chemotherapy Treatments of Liver Cancer. Acta Biomaterialia,110, 221-230. |
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File Description--f29283 |
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File: Figure 7G statistics calculation.tab |
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UNF:6:CgWydUb+URiN2s1BBJxPHw== |
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List of Variables: |
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f29283 Location: |
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