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Part 1: Document Description
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Citation |
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Title: |
Integrated Analysis of the Plasmodium Species Transcriptome |
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Identification Number: |
doi:10.21979/N9/UBCFAP |
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Distributor: |
DR-NTU (Data) |
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Date of Distribution: |
2019-07-08 |
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Version: |
1 |
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Bibliographic Citation: |
Hoo, Regina May Ling, 2019, "Integrated Analysis of the Plasmodium Species Transcriptome", https://doi.org/10.21979/N9/UBCFAP, DR-NTU (Data), V1, UNF:6:1IVTRLN2QZa2dxWQtdfWVw== [fileUNF] |
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Citation |
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Title: |
Integrated Analysis of the Plasmodium Species Transcriptome |
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Identification Number: |
doi:10.21979/N9/UBCFAP |
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Authoring Entity: |
Hoo, Regina May Ling (Nanyang Technological University) |
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Software used in Production: |
R |
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Grant Number: |
NMRC/1292/2011 |
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Grant Number: |
1R01AI24710 |
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Grant Number: |
R01-AI065961 |
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Grant Number: |
ORIP/OD P51OD011132 |
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Distributor: |
DR-NTU (Data) |
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Access Authority: |
Hoo, Regina May Ling |
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Depositor: |
Hoo, Regina May Ling |
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Date of Deposit: |
2019-07-05 |
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Holdings Information: |
https://doi.org/10.21979/N9/UBCFAP |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, malaria, transcriptome |
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Abstract: |
The genome sequence available for different Plasmodium species is a valuable resource for understanding malaria parasite biology. However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. Here, we developed a comprehensive approach to measure transcriptional changes of the evolutionary conserved syntenic orthologs during the intraerythrocytic developmental cycle across six Plasmodium species. We show significant transcriptional constraint at the mid-developmental stage of Plasmodium species while the earliest stages of parasite development display the greatest transcriptional variation associated with critical functional processes. Modeling of the evolutionary relationship based on changes in transcriptional profile reveal a phylogeny pattern of the Plasmodium species that strictly follows its mammalian hosts. In addition, the work shows that transcriptional conserved orthologs represent potential future targets for anti-malaria intervention as they would be expected to carry out key essential functions within the parasites. This work provides an integrated analysis of orthologs transcriptome, which aims to provide insights into the Plasmodium evolution thereby establishing a framework to explore complex pathways and drug discovery in Plasmodium species with broad host range. |
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Kind of Data: |
Microarray data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
10.1016/j.ebiom.2016.04.011 |
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Bibliographic Citation: |
Hoo, R., Zhu, L., Amaladoss, A., Mok, S., Natalang, O., Lapp, S. A., . . . Preiser, P. R. (2016). Integrated analysis of the Plasmodium species transcriptome. EBioMedicine, 7(1), 255-266. |
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Citation |
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Identification Number: |
10356/89991 |
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Bibliographic Citation: |
Hoo, R., Zhu, L., Amaladoss, A., Mok, S., Natalang, O., Lapp, S. A., . . . Preiser, P. R. (2016). Integrated analysis of the Plasmodium species transcriptome. EBioMedicine, 7(1), 255-266. |
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File Description--f12784 |
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File: Table S1.tab |
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Notes: |
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File Description--f12786 |
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File: Table S3.tab |
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Notes: |
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File Description--f12783 |
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File: Table S4.tab |
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UNF:6:uRkUj33E0IIDS5jQT2GI6A== |
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List of Variables: |
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Variables |
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SupplementaryTable1:ProcessedmicroarrayhybridizationdataofP.falciparum(24time-points),P.knowlesi(7time-points),P.vivax(9time-points),P.yoelii(12time-points),P.berghei(12time-points)andP.chabaudi(12time-points)IDCtranscriptome |
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SupplementaryTable4:Listof240transcriptionallyconservedorthologswithpositivedruggabilityindexscore(DIS)obtainedfromTDRdatabase,withitscorrespondingpeakexpressioninIDC,relatedtoFigure6.YdenotesessentialityevidenceinP.bergheiknockoutstudiesfromRMgmDB. |
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Extended Data Fig 1.tif |
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