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Part 1: Document Description
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Citation |
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Title: |
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice |
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Identification Number: |
doi:10.21979/N9/9J9BWD |
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Distributor: |
DR-NTU (Data) |
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Date of Distribution: |
2021-03-22 |
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Version: |
1 |
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Bibliographic Citation: |
Chen Qi; Lai Simin; Xu Shaohai; Tan Yingrou; Leong Keith; Liu Dehua; Tan Jiachi; Naik Roshan Ratnakar; Barron Anna M; Sunil S. Adav; Chen Jinmiao; Chong Shuzhen; Ng Laiguan; Ruedl Christiane, 2021, "Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice", https://doi.org/10.21979/N9/9J9BWD, DR-NTU (Data), V1 |
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Citation |
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Title: |
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice |
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Identification Number: |
doi:10.21979/N9/9J9BWD |
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Authoring Entity: |
Chen Qi (Nanyang Technological University) |
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Lai Simin (Nanyang Technological University) |
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Xu Shaohai (Nanyang Technological University) |
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Tan Yingrou (Agency for Science, Technology and Research (A*STAR)) |
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Leong Keith (Agency for Science, Technology and Research (A*STAR)) |
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Liu Dehua (Agency for Science, Technology and Research (A*STAR)) |
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Tan Jiachi (Agency for Science, Technology and Research (A*STAR)) |
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Naik Roshan Ratnakar (Nanyang Technological University) |
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Barron Anna M (Nanyang Technological University) |
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Sunil S. Adav (Nanyang Technological University) |
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Chen Jinmiao (Agency for Science, Technology and Research (A*STAR)) |
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Chong Shuzhen (Agency for Science, Technology and Research (A*STAR)) |
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Ng Laiguan (Agency for Science, Technology and Research (A*STAR)) |
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Ruedl Christiane (Nanyang Technological University) |
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Software used in Production: |
Flow Jo |
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Grant Number: |
MOE2018-T2-2-016 |
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Distributor: |
DR-NTU (Data) |
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Access Authority: |
Ruedl, Christiane |
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Depositor: |
Ruedl, Christiane |
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Date of Deposit: |
2021-03-22 |
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Holdings Information: |
https://doi.org/10.21979/N9/9J9BWD |
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Study Scope |
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Keywords: |
Medicine, Health and Life Sciences, Medicine, Health and Life Sciences, tissue resident macrophages; white adipose tissue; remodelling; vascular integrity; CD169-DTR mouse; inflammation; lipid-accumulating macrophages; fibrosis; obesity |
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Abstract: |
Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to the metabolic changes of their microenvironment that are often induced by excess energy intake. Currently, the exact contribution of these macrophages in obesity-driven WAT remodeling remains controversial. Here, using a transgenic CD169-DTR mouse strain, we provide new insights into the interplay between CD169+ adipose tissue macrophages (ATMs) and their surrounding WAT microenvironment. Using targeted in vivo ATM ablation followed by transcriptional and metabolic WAT profiling, we found that ATMs protect WAT from the excessive pathological remodeling that occurs during obesity. As obesity progresses, ATMs control not only vascular integrity, adipocyte function, and lipid and metabolic derangements but also extracellular matrix accumulation and resultant fibrosis in the WAT. The protective role of ATMs during obesity-driven WAT dysfunction supports the notion that ATMs represent friends, rather than foes, as has previously assumed. |
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Kind of Data: |
Raw experimental data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
10.15252/embr.202152835 |
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Bibliographic Citation: |
Chen, Q., Lai, S. M., Xu, S., Tan, Y., Leong, K., Liu, D., ... & Ruedl, C. (2021). Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice. EMBO reports, e52835. |
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Citation |
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Identification Number: |
10356/155110 |
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Bibliographic Citation: |
Chen, Q., Lai, S. M., Xu, S., Tan, Y., Leong, K., Liu, D., Tan, J. C., Naik, R. R., Barron, A. M., Adav, S. S., Chen, J., Chong, S. Z., Ng, L. G. & Ruedl, C. (2021). Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice. EMBO Reports, 22(8), e52835-. |
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Figure 1.zip |
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application/zip |
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Figure 2.zip |
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Figure 3.zip |
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Figure 5.zip |
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Figure 7.zip |
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Figure EV1.zip |
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Figure EV3.zip |
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Figure EV8.zip |
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