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Part 1: Document Description
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Citation |
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Title: |
Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans |
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Identification Number: |
doi:10.21979/N9/MGPD5H |
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Distributor: |
DR-NTU (Data) |
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Date of Distribution: |
2020-05-27 |
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Version: |
1 |
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Bibliographic Citation: |
Beaudoin-Chabot, Caroline; Lei, Wang; Shchepinov, Mikhail S.; Smarun, Alexey V.; Vidović, Drasko; Thibault, Guillaume, 2020, "Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans", https://doi.org/10.21979/N9/MGPD5H, DR-NTU (Data), V1, UNF:6:vX21yKAg/6svjOec2AP1IA== [fileUNF] |
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Citation |
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Title: |
Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans |
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Identification Number: |
doi:10.21979/N9/MGPD5H |
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Authoring Entity: |
Beaudoin-Chabot, Caroline (Nanyang Technological University) |
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Lei, Wang (Nanyang Technological University) |
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Shchepinov, Mikhail S. (Retrotope) |
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Smarun, Alexey V. (Monash University) |
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Vidović, Drasko (Monash University) |
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Thibault, Guillaume (Nanyang Technological University) |
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Software used in Production: |
Microsoft Excel 2013 |
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Grant Number: |
Nanyang Assistant Professorship program |
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Grant Number: |
Academic Research Fund Tier 2 MOE2018-T2-1-002 |
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Distributor: |
DR-NTU (Data) |
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Access Authority: |
Thibault, Guillaume |
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Depositor: |
Beaudoin-Chabot, Caroline |
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Date of Deposit: |
2019-04-29 |
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Holdings Information: |
https://doi.org/10.21979/N9/MGPD5H |
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Study Scope |
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Keywords: |
Chemistry, Medicine, Health and Life Sciences, Chemistry, Medicine, Health and Life Sciences, polyunsaturated fatty acid (PUFA), deuterated fatty acid, oxidative stress, lipid peroxidation, lifespan, C. elegans, essential fatty acids, linolenic acid |
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Abstract: |
Chemically reinforced essential fatty acids promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential fatty acids with the isotope deuterium. This substitution leads to a significantly slower oxidation due to the kinetic isotope effect, inhibiting membrane damage. The approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralise beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in C. elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings demonstrate that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan. |
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Kind of Data: |
Experimental data |
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Methodology and Processing |
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Sources Statement |
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Data Access |
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Other Study Description Materials |
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Related Publications |
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Citation |
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Identification Number: |
10.3389/fphys.2019.00641 |
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Bibliographic Citation: |
Beaudoin-Chabot, C., Wang, L., Smarun, A. V., Vidović, D., Shchepinov, M. S., & Thibault, G. (2019). Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Frontiers in physiology, 10, 641-. |
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Citation |
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Identification Number: |
10356/142058 |
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Bibliographic Citation: |
Beaudoin-Chabot, C., Wang, L., Smarun, A. V., Vidović, D., Shchepinov, M. S., & Thibault, G. (2019). Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Frontiers in Physiology, 10, 641-. |
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File Description--f9795 |
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File: Fig_1F_Part_1.tab |
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Notes: |
UNF:6:wYrkccWtrVT02on/yFBjbQ== |
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File Description--f9794 |
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File: Fig_1G.tab |
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Notes: |
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Label: |
Figure 1.zip |
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Text: | |
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application/zip |
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Figure 2.zip |
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application/zip |
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Figure 3.zip |
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application/zip |
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Figure 4.zip |
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application/zip |