<?xml version='1.0' encoding='UTF-8'?><codeBook xmlns="ddi:codebook:2_5" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:codebook:2_5 https://ddialliance.org/Specification/DDI-Codebook/2.5/XMLSchema/codebook.xsd" version="2.5"><docDscr><citation><titlStmt><titl>Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans</titl><IDNo agency="DOI">doi:10.21979/N9/MGPD5H</IDNo></titlStmt><distStmt><distrbtr source="archive">DR-NTU (Data)</distrbtr><distDate>2020-05-27</distDate></distStmt><verStmt source="archive"><version date="2020-06-18" type="RELEASED">1</version></verStmt><biblCit>Beaudoin-Chabot, Caroline; Lei, Wang; Shchepinov, Mikhail S.; Smarun, Alexey V.; Vidović, Drasko; Thibault, Guillaume, 2020, "Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans", https://doi.org/10.21979/N9/MGPD5H, DR-NTU (Data), V1, UNF:6:vX21yKAg/6svjOec2AP1IA== [fileUNF]</biblCit></citation></docDscr><stdyDscr><citation><titlStmt><titl>Related Data for: Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans</titl><IDNo agency="DOI">doi:10.21979/N9/MGPD5H</IDNo></titlStmt><rspStmt><AuthEnty affiliation="Nanyang Technological University">Beaudoin-Chabot, Caroline</AuthEnty><AuthEnty affiliation="Nanyang Technological University">Lei, Wang</AuthEnty><AuthEnty affiliation="Retrotope">Shchepinov, Mikhail S.</AuthEnty><AuthEnty affiliation="Monash University">Smarun, Alexey V.</AuthEnty><AuthEnty affiliation="Monash University">Vidović, Drasko</AuthEnty><AuthEnty affiliation="Nanyang Technological University">Thibault, Guillaume</AuthEnty></rspStmt><prodStmt><software version="2013">Microsoft Excel 2013</software><grantNo agency="Nanyang Technological University">Nanyang Assistant Professorship program</grantNo><grantNo agency="Ministry of Education (MOE)">Academic Research Fund Tier 2 MOE2018-T2-1-002</grantNo></prodStmt><distStmt><distrbtr source="archive">DR-NTU (Data)</distrbtr><contact affiliation="Nanyang Technological University">Thibault, Guillaume</contact><depositr>Beaudoin-Chabot, Caroline</depositr><depDate>2019-04-29</depDate></distStmt><holdings URI="https://doi.org/10.21979/N9/MGPD5H"/></citation><stdyInfo><subject><keyword xml:lang="en">Chemistry</keyword><keyword xml:lang="en">Medicine, Health and Life Sciences</keyword><keyword>Chemistry</keyword><keyword>Medicine, Health and Life Sciences</keyword><keyword>polyunsaturated fatty acid (PUFA), deuterated fatty acid, oxidative stress, lipid peroxidation, lifespan, C. elegans, essential fatty acids, linolenic acid</keyword></subject><abstract date="2019-04-29">Chemically reinforced essential fatty acids promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential fatty acids with the isotope deuterium. This substitution leads to a significantly slower oxidation due to the kinetic isotope effect, inhibiting membrane damage. The approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralise beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in C. elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings demonstrate that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan.</abstract><sumDscr><dataKind>Experimental data</dataKind></sumDscr></stdyInfo><method><dataColl><sources/></dataColl><anlyInfo/></method><dataAccs><setAvail/><useStmt/></dataAccs><othrStdyMat><relPubl><citation><titlStmt><IDNo agency="doi">10.3389/fphys.2019.00641</IDNo></titlStmt><biblCit>Beaudoin-Chabot, C., Wang, L., Smarun, A. V., Vidović, D., Shchepinov, M. S., & Thibault, G. (2019). Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Frontiers in physiology, 10, 641-.</biblCit></citation><ExtLink URI="https://www.frontiersin.org/articles/10.3389/fphys.2019.00641/full"/></relPubl><relPubl><citation><titlStmt><IDNo agency="handle">10356/142058</IDNo></titlStmt><biblCit>Beaudoin-Chabot, C., Wang, L., Smarun, A. V., Vidović, D., Shchepinov, M. S., & Thibault, G. (2019). Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Frontiers in Physiology, 10, 641-.</biblCit></citation><ExtLink URI="https://hdl.handle.net/10356/142058"/></relPubl></othrStdyMat></stdyDscr><fileDscr ID="f9795" URI="https://researchdata.ntu.edu.sg/api/access/datafile/9795"><fileTxt><fileName>Fig_1F_Part_1.tab</fileName><dimensns><caseQnty>55</caseQnty><varQnty>17</varQnty></dimensns><fileType>text/tab-separated-values</fileType></fileTxt><notes level="file" type="VDC:UNF" subject="Universal Numeric Fingerprint">UNF:6:wYrkccWtrVT02on/yFBjbQ==</notes></fileDscr><fileDscr ID="f9794" URI="https://researchdata.ntu.edu.sg/api/access/datafile/9794"><fileTxt><fileName>Fig_1G.tab</fileName><dimensns><caseQnty>17</caseQnty><varQnty>7</varQnty></dimensns><fileType>text/tab-separated-values</fileType></fileTxt><notes level="file" type="VDC:UNF" subject="Universal Numeric Fingerprint">UNF:6:PeXM6KjIcHQL8qBuXvTBYQ==</notes></fileDscr><dataDscr><var ID="v7919" name="43041" intrvl="discrete"><location fileid="f9795"/><labl level="variable">43041</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:xz/id1GDj+jf7iuvJrGAkg==</notes></var><var ID="v7915" name="B" intrvl="discrete"><location fileid="f9795"/><labl level="variable">B</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:eVXTQNdRcEKPRn9/7S368Q==</notes></var><var ID="v7912" name="C" intrvl="discrete"><location fileid="f9795"/><labl level="variable">C</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:zMJR8thrYtY9IfwNJN0z3w==</notes></var><var ID="v7918" name="D" intrvl="discrete"><location fileid="f9795"/><labl level="variable">D</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:oDyGRUZWtyERudVXQw/XdQ==</notes></var><var ID="v7910" name="E" intrvl="discrete"><location fileid="f9795"/><labl level="variable">E</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:vq4/0NNXg53cS1ltY4r09A==</notes></var><var ID="v7904" name="F" intrvl="discrete"><location fileid="f9795"/><labl level="variable">F</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:K9lBQiBplQbzLdd+VWDUzw==</notes></var><var ID="v7917" name="42991" intrvl="discrete"><location fileid="f9795"/><labl level="variable">42991</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:x0HFkq3T0A5VCvmWR00Sfw==</notes></var><var ID="v7907" name="H" intrvl="discrete"><location fileid="f9795"/><labl level="variable">H</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:O0rm6bKVoF/RP7YHpo2Dmg==</notes></var><var ID="v7913" name="I" intrvl="discrete"><location fileid="f9795"/><labl level="variable">I</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:Jq4Bntwm1dFOajYbVG4o5A==</notes></var><var ID="v7905" name="J" intrvl="discrete"><location fileid="f9795"/><labl level="variable">J</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:OHIHQsG0T5K90uCG0mqlFA==</notes></var><var ID="v7908" name="K" intrvl="discrete"><location fileid="f9795"/><labl level="variable">K</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:X2fXohlwmjD4fpfFzve13w==</notes></var><var ID="v7906" name="L" intrvl="discrete"><location fileid="f9795"/><labl level="variable">L</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:9pQWRoNcYqh5/tEFOtFjiQ==</notes></var><var ID="v7916" name="43012" intrvl="discrete"><location fileid="f9795"/><labl level="variable">43012</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:f6pt+m8MXkltFjQQvbIdrA==</notes></var><var ID="v7909" name="N" intrvl="discrete"><location fileid="f9795"/><labl level="variable">N</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:CtXfjKAN+2/yy6qlLW9VoA==</notes></var><var ID="v7914" name="O" intrvl="discrete"><location fileid="f9795"/><labl level="variable">O</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:cwhbqzyiXD7Ol3O7US5Byw==</notes></var><var ID="v7903" name="P" intrvl="discrete"><location fileid="f9795"/><labl level="variable">P</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:cKfKNq5ia7SBE81Bd9F+CQ==</notes></var><var ID="v7911" name="Q" intrvl="discrete"><location fileid="f9795"/><labl level="variable">Q</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:O66aW++LWc4sklNePi4kTw==</notes></var><var ID="v7897" name="N2" intrvl="contin"><location fileid="f9794"/><labl level="variable">N2</labl><sumStat type="max">338.0</sumStat><sumStat type="stdev">30.27914573872035</sumStat><sumStat type="vald">16.0</sumStat><sumStat type="invd">1.0</sumStat><sumStat type="min">211.0</sumStat><sumStat type="mode">.</sumStat><sumStat type="medn">263.0</sumStat><sumStat type="mean">265.8</sumStat><varFormat type="numeric"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:hvTEPywfh+WXVunSbJJCIA==</notes></var><var ID="v7896" name="fat-1" intrvl="contin"><location fileid="f9794"/><labl level="variable">fat-1</labl><sumStat type="mean">158.05490199281962</sumStat><sumStat type="stdev">46.57226890619002</sumStat><sumStat type="mode">.</sumStat><sumStat type="medn">155.0</sumStat><sumStat type="max">220.0</sumStat><sumStat type="min">5.446001905739005E-7</sumStat><sumStat type="vald">17.0</sumStat><sumStat type="invd">0.0</sumStat><varFormat type="numeric"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:HwYZ6LTVSnUGeI0JODkxbg==</notes></var><var ID="v7900" name="fat-1TAG" intrvl="contin"><location fileid="f9794"/><labl level="variable">fat-1TAG</labl><sumStat type="medn">157.0</sumStat><sumStat type="invd">0.0</sumStat><sumStat type="vald">17.0</sumStat><sumStat type="mean">152.55544616366385</sumStat><sumStat type="max">202.0</sumStat><sumStat type="stdev">42.90320146676626</sumStat><sumStat type="mode">.</sumStat><sumStat type="min">0.3759181156186747</sumStat><varFormat type="numeric"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:X3HuSOome75yOUvdY3NTGw==</notes></var><var ID="v7902" name="fat-1DTAG" intrvl="contin"><location fileid="f9794"/><labl level="variable">fat-1DTAG</labl><sumStat type="vald">17.0</sumStat><sumStat type="stdev">66.32519501773724</sumStat><sumStat type="invd">0.0</sumStat><sumStat type="mode">.</sumStat><sumStat type="medn">243.0</sumStat><sumStat type="max">299.0</sumStat><sumStat type="mean">228.9568630325317</sumStat><sumStat type="min">4.886372028711503E-6</sumStat><varFormat type="numeric"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:ODsZXnH5HP05RcvXkKyGFA==</notes></var><var ID="v7898" name="E" intrvl="contin"><location fileid="f9794"/><labl level="variable">E</labl><sumStat type="min">NaN</sumStat><sumStat type="stdev">NaN</sumStat><sumStat type="mode">.</sumStat><sumStat type="medn">NaN</sumStat><sumStat type="invd">17.0</sumStat><sumStat type="mean">NaN</sumStat><sumStat type="max">NaN</sumStat><sumStat type="vald">0.0</sumStat><varFormat type="numeric"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:jo/kfkozsXi/BDPYBQywrQ==</notes></var><var ID="v7899" name="F" intrvl="contin"><location fileid="f9794"/><labl level="variable">F</labl><sumStat type="min">NaN</sumStat><sumStat type="vald">0.0</sumStat><sumStat type="mode">.</sumStat><sumStat type="stdev">NaN</sumStat><sumStat type="max">NaN</sumStat><sumStat type="mean">NaN</sumStat><sumStat type="invd">17.0</sumStat><sumStat type="medn">NaN</sumStat><varFormat type="numeric"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:jo/kfkozsXi/BDPYBQywrQ==</notes></var><var ID="v7901" name="G" intrvl="discrete"><location fileid="f9794"/><labl level="variable">G</labl><varFormat type="character"/><notes subject="Universal Numeric Fingerprint" level="variable" type="Dataverse:UNF">UNF:6:hb/O6hv25GlAx3ZQfa5t2w==</notes></var></dataDscr><otherMat ID="f13596" URI="https://researchdata.ntu.edu.sg/api/access/datafile/13596" level="datafile"><labl>Figure 1.zip</labl><txt></txt><notes level="file" type="DATAVERSE:CONTENTTYPE" subject="Content/MIME Type">application/zip</notes></otherMat><otherMat ID="f13597" URI="https://researchdata.ntu.edu.sg/api/access/datafile/13597" level="datafile"><labl>Figure 2.zip</labl><txt></txt><notes level="file" type="DATAVERSE:CONTENTTYPE" subject="Content/MIME Type">application/zip</notes></otherMat><otherMat ID="f13598" URI="https://researchdata.ntu.edu.sg/api/access/datafile/13598" level="datafile"><labl>Figure 3.zip</labl><txt></txt><notes level="file" type="DATAVERSE:CONTENTTYPE" subject="Content/MIME Type">application/zip</notes></otherMat><otherMat ID="f13599" URI="https://researchdata.ntu.edu.sg/api/access/datafile/13599" level="datafile"><labl>Figure 4.zip</labl><txt></txt><notes level="file" type="DATAVERSE:CONTENTTYPE" subject="Content/MIME Type">application/zip</notes></otherMat></codeBook>